Search Result

Results for "

antinociceptive effects

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adenosine Receptor (4) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (4) Bacterial (2) Calcium Channel (1) Cannabinoid Receptor (2) CCR (1) COX (1) Cytochrome P450 (1) Dopamine Receptor (1) Endogenous Metabolite (4) Formyl Peptide Receptor (FPR) (1) Fungal (1) Insulin Receptor (1) Isotope-Labeled Compounds (1) MAGL (1) nAChR (1) NF-κB (2) NO Synthase (1) Nucleoside Antimetabolite/Analog (1) Opioid Receptor (8) P2X Receptor (3) Parasite (1) Potassium Channel (1) Reactive Oxygen Species (1) SARS-CoV (1) Sigma Receptor (2) Sodium Channel (1) Src (1) Trk Receptor (1) TRP Channel (3)
By Research Areas:	Cancer (11) Cardiovascular Disease (3) Endocrinology (1) Infection (5) Inflammation/Immunology (20) Metabolic Disease (3) Neurological Disease (29)

By Targets:

5-HT Receptor (1)

Adenosine Receptor (4)

Angiotensin-converting Enzyme (ACE) (1)

Apoptosis (4)

Bacterial (2)

Calcium Channel (1)

Cannabinoid Receptor (2)

CCR (1)

COX (1)

Cytochrome P450 (1)

Dopamine Receptor (1)

Endogenous Metabolite (4)

Formyl Peptide Receptor (FPR) (1)

Fungal (1)

Insulin Receptor (1)

Isotope-Labeled Compounds (1)

MAGL (1)

nAChR (1)

NF-κB (2)

NO Synthase (1)

Nucleoside Antimetabolite/Analog (1)

Opioid Receptor (8)

P2X Receptor (3)

Parasite (1)

Potassium Channel (1)

Reactive Oxygen Species (1)

SARS-CoV (1)

Sigma Receptor (2)

Sodium Channel (1)

Src (1)

Trk Receptor (1)

TRP Channel (3)

By Research Areas:

Cancer (11)

Cardiovascular Disease (3)

Endocrinology (1)

Infection (5)

Inflammation/Immunology (20)

Metabolic Disease (3)

Neurological Disease (29)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3870A

DALDA acetate	Opioid Receptor	Neurological Disease
DALDA acetate is a potent and highly selective μ-opioid receptor agonist with a K_i of 1.69 nM. DALDA acetate shows antinociceptive and respiratory effects .

HY-N9502

Linalool oxide	Others	Neurological Disease
Linalool oxide is a secondary metabolite in elongating wheat plants with antinociceptive and anticonvulsant effects. Linalool oxide shows anxiolytic activity .

HY-145169

AZ194	Sodium Channel	Neurological Disease
AZ194 is a first-in-class, orally active inhibitor of CRMP2-Ubc9 interaction and inhibitor of NaV1.7 (IC₅₀=1.2 μM). AZ194 blocks SUMOylation of CRMP2 to selectively reduce the amount of surface-expressed NaV1.7. Antinociceptive effects .

HY-N0388

Gelsemine

Others Neurological Disease

Gelsemine, an alkaloid from the Chinese herb Gelsemium elegans, is effective in mitigating chronic pain. Antinociceptive effects.

Gelsemine	Others	Neurological Disease
Gelsemine, an alkaloid from the Chinese herb Gelsemium elegans, is effective in mitigating chronic pain. Antinociceptive effects.

HY-P3870

DALDA	Opioid Receptor	Neurological Disease
DALDA is a potent and highly selective μ-opioid receptor agonist with a K_i of 1.69 nM. DALDA shows antinociceptive and respiratory effects .

HY-103341

UCM707	Cannabinoid Receptor	Neurological Disease
UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of Anandamide .

HY-N0037

Albiflorin 2 Publications Verification	Reactive Oxygen Species	Inflammation/Immunology
Albiflorin, a major constituent contained in peony root, is a monoterpene glycoside with neuroprotective effects. Albiflorin also has anti-inflammatory, antioxidant and antinociceptive effects .

HY-N7083

Citral 1 Publications Verification	Others	Inflammation/Immunology Cancer
Citral is a monoterpene found in Cymbopogon citratus essential oil, with antihyperalgesic, anti-nociceptive and anti-inflammatory effects .

HY-N0628

Kaempferitrin 1 Publications Verification Lespedin; Lespenephryl	Insulin Receptor	Metabolic Disease Endocrinology Cancer
Kaempferitrin is a natural flavonoid, possesses antinociceptive, anti-inflammatory, anti-diabetic, antitumoral and chemopreventive effects, and activates insulin signaling pathway.

HY-78131B

(R)-(-)-Ibuprofen 2 Publications Verification (R)-Ibuprofen	NF-κB	Inflammation/Immunology Cancer
(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.

HY-108667

TNP-ATP triethylammonium

P2X Receptor Others

TNP-ATP triethylammonium is a selective P2X receptor antagonist. TNP-ATP triethylammonium shows antinociceptive effects in rats .

TNP-ATP triethylammonium	P2X Receptor	Others
TNP-ATP triethylammonium is a selective P2X receptor antagonist. TNP-ATP triethylammonium shows antinociceptive effects in rats .

HY-107741

SNC162	Opioid Receptor	Neurological Disease
SNC162 is a delta-opioid receptor agonist with an IC₅₀ of 0.94 nM. SNC162 has antidepressant-like effects and produces a selective enhancement of the antinociceptive effects of fentanyl in rhesus monkeys .

HY-118785

MSP-3

TRP Channel Neurological Disease

MSP-3 is a potent TRPV1 agonist, with an EC₅₀ of 0.87 μM. MSP-3 exhibits neuroprotective and antinociceptive effects .

MSP-3	TRP Channel	Neurological Disease
MSP-3 is a potent TRPV1 agonist, with an EC₅₀ of 0.87 μM. MSP-3 exhibits neuroprotective and antinociceptive effects .

HY-P3870B

DALDA TFA	Opioid Receptor	Neurological Disease
DALDA TFA is a potent and highly selective μ-opioid receptor agonist with a K_i of 1.69 nM. DALDA TFA shows antinociceptive and respiratory effects .

HY-W436270

Bulbocapnine hydrochloride	Dopamine Receptor	Neurological Disease Inflammation/Immunology
Bulbocapnine hydrochloride, an aporphine alkaloid, is a dopamine receptor inhibitor. Bulbocapnine hydrochloride inhibits dopamine synthesis. Bulbocapnine hydrochloride also has neuroleptic-like, anticonvulsant and antinociceptive effects .

HY-137988

Palvanil	TRP Channel	Neurological Disease Inflammation/Immunology
Palvanil is a Capsaicin (HY-10448) analogue, shows strong desensitizing capability against the TRPV1 receptor. Palvanil shows anti-nociceptive and anti-inflammation effects .

HY-69019

7-Nitroindazole 1 Publications Verification	NO Synthase	Cardiovascular Disease Neurological Disease
7-Nitroindazole is a selective nNOS inhibitor with antinociceptive and cardiovascular effects. 7-Nitroindazole is a useful tool to evaluate the biological roles of nitric oxide in the central nervous system .

HY-N7144A

Citronellyl acetate	Apoptosis	Infection Cancer
Citronellyl acetate is a monoterpene product of the secondary metabolism of plants, with antinociceptive activity. Citronellyl acetate exhibits pro-apoptotic activity in human hepatoma cells. Citronellyl acetate shows fungicidal, larvicidal, bactericidal and repelling/insecticidal effects .

HY-78131BS

(R)-(-)-Ibuprofen-d3 (R)-Ibuprofen-d₃	NF-κB	Inflammation/Immunology Cancer
(R)-(-)-Ibuprofen-d₃ is the deuterium labeled (R)-(-)-Ibuprofen. (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.

HY-P1795

N-Boc-Phe-Leu-Phe-Leu-Phe 1 Publications Verification Boc-FLFLF	Formyl Peptide Receptor (FPR)	Neurological Disease
N-Boc-Phe-Leu-Phe-Leu-Phe (Boc-FLFLF) is a formyl peptide receptor 1 (FPR1) antagonist, which increases pain effects and inhibits antinociceptive activity of annexin .

HY-148166

L-Inosine	Nucleoside Antimetabolite/Analog	Others
L-Inosine is the L-configuration of Inosine (HY-N0092). Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects .

HY-100812

2-Hydroxysaclofen
2-Hydroxysaclofen is a potent γ-amino-butyric-acid-B (GABA_B) receptor antagonist. 2-Hydroxysaclofen can abolish nicotine-induced hypolocomotor effects and increases the antinociceptive effects. 2-Hydroxysaclofen can stimulate luteinizing hormone (LH) secretion in female rats .

HY-112692

AT-121	Opioid Receptor	Neurological Disease
AT-121 is a bifunctional nociception and mu opioid receptor agonist, with K_is of 3.67 and 16.49 nM, respectively. AT-121 is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects .

HY-112692A

AT-121 hydrochloride	Opioid Receptor	Neurological Disease
AT-121 hydrochloride is a bifunctional nociception and mu opioid receptor agonist, with K_is of 3.67 and 16.49 nM, respectively. AT-121 hydrochloride is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects .

HY-N0092S1

Inosine-13C	Adenosine Receptor Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Inosine- ¹³C is the ¹³C labeled Inosine. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A

HY-N0746

Oxysophocarpine 4 Publications Verification	Others	Cancer
Oxysophocarpine is an alkaloid extracted from Sophora alopecuroides. Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems . Oxysophocarpine inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC) .

HY-151949

TrkA-IN-4	Trk Receptor	Neurological Disease
TrkA-IN-4, a potent, orally active and allosteric TrkA inhibitor, is a proagent of TrkA-IN-3 (IC₅₀=22.4 nM, HY-151948). TrkA-IN-4 exhibits potent antinociceptive effects .

HY-108964

Carvone	Bacterial	Infection Neurological Disease Inflammation/Immunology
Carvone is a ketone monoterpene found mostly in the essential oils from plants of the genus Mentha. Carvone is widely used in the pharmaceutical industry, cosmetics and agriculture. Carvone has such effects as antimicrobial, antioxidant, anti-inflammatory, antispasmodic, antinociceptive, anticonvulsant .

HY-14316

Tebanicline Ebanicline; ABT-594	nAChR	Neurological Disease
Tebanicline, an analogue of epibatidine, is a neuronal nicotinic acetylcholine receptor agonist. Tebanicline exhibits potent antinociceptive effects and has a high affinity for the α4β2 neuronal nicotinic acetylcholine receptor subunit in the central nervous system.

HY-N0092

Inosine 5 Publications Verification	Adenosine Receptor Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-N2165

Vicenin 2 2 Publications Verification	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Vicenin 2, a flavonoid, is an orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀ of 43.83 μM) . Vicenin 2 has radioprotective, anti-nociceptive effects, anti-glycation anti-inflammatory, antioxidant, anticancer, antiangiogenic properties .

HY-122219

R243	CCR	Inflammation/Immunology
R243 is a potent and selective CCR8 antagonist. R243 inhibits CCL₁/CCR8 interaction and inhibits CCR8 signaling and chemotaxis. R243 has antinociceptive and anti-inflammatory effects .

HY-145628

CM398	Sigma Receptor	Neurological Disease Inflammation/Immunology
CM398 is a highly selective, orally active sigma-2 receptor ligand (K_i=0.43 nM), with high sigma-1/sigma-2 selectivity rato (1000-fold). CM398 shows notable affinity for dopamine (K_i=32.90 nM) and serotonin transporters (K_i=244.2 nM). CM398 shows promising anti-inflammatory analgesic effects in the formalin model of inflammatory pain in mice .

HY-N0092S4

Inosine-13C3	Isotope-Labeled Compounds	Others
Inosine-13C3 is a ¹³C-labeled Inosine that can be used in pharmacokinetic studies of Inosine. Inosine is an agonist of adenosine receptors A₁R and A_2AR with anti-inflammatory immunomodulatory, antinociceptive and neuroprotective effects .

HY-N9854

Icariside E4	Potassium Channel	Inflammation/Immunology
Icariside E4 is an antinociceptive agent, and can be isolated from Tabebuia roseo-alba. Icariside E4 has peripheral analgesic activity by ATP-sensitive K ⁺ channel-dependent mechanisms. Icariside E4 also has anti-oxidant, anti-Alzheimer and anti-inflammatory effects .

HY-128865

BPR1M97	Opioid Receptor	Neurological Disease
BPR1M97 is a dual-acting mu opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist with K_i values of 1.8 and 4.2 nM, respectively. BPR1M97 shows high potency and blood-brain barrier penetration, and produces potent antinociceptive effects .

HY-110150

UNC3230 5 Publications Verification	Others	Inflammation/Immunology Cancer
UNC3230 is a potent, selective and ATP-competitive PIP5K1C inhibitor with an IC₅₀ of ~41 nM. UNC3230 also inhibits PIP4K2C and does not inhibit any of the other lipid kinases that regulate phosphoinositide levels. UNC3230 has antinociceptive and anticancer effects .

HY-101379A

8-Bromo-cGMP sodium 1 Publications Verification	Calcium Channel	Cardiovascular Disease Neurological Disease
8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator. 8-Bromo-cGMP sodium significantly inhibits Ca ²⁺ macroscopic currents and impairs insulin release stimulated with high K ⁺ . 8-Bromo-cGMP sodium has antinociceptive effects and results in vasodilator responses .

HY-N5025

Bullatine A	P2X Receptor Apoptosis	Inflammation/Immunology Cancer
Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A is a potent P2X7 antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses . Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed .

HY-130605

BAY-1797 2 Publications Verification	P2X Receptor	Neurological Disease
BAY-1797 is a potent, orally active, and selective P2X4 antagonist, with an IC₅₀ of 211 nM against human P2X4. BAY-1797 displays no or very weak activity on the other P2X ion channels. BAY-1797 shows anti-nociceptive and anti-inflammatory effects .

HY-N0092S

Inosine-2,8-d2	Adenosine Receptor Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Inosine-2,8-d₂ is the deuterium labeled Inosine. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors[1][2][3].

HY-N6962

α-Spinasterol	TRP Channel COX Bacterial	Infection Neurological Disease
α-Spinasterol, isolated from Melandrium firmum, has antibacterial activity . α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC₅₀ values of 16.17 μM and 7.76 μM, respectively .

HY-101202A

(Rac)-SNC80 (Rac)-NIH 10815	Opioid Receptor	Neurological Disease
(Rac)-SNC80 is a racemate of SNC80 (HY-101202). SNC80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist with a K_i of 1.78 nM and an IC₅₀ of 2.73 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment .

HY-N0092S3

Inosine-13C10,15N4	Adenosine Receptor Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Inosine-13C10,15N4 is ¹³C and ¹⁵N labeled Inosine (HY-N0092). Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-108485

Damnacanthal	Src Apoptosis Fungal	Infection Inflammation/Immunology Cancer
Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56 ^lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 ^lck autophosphorylation and phosphorylation of exogenous substrates with IC₅₀s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against *Candida albicans* .

HY-101202

SNC80 NIH 10815
SNC80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist with a K_i of 1.78 nM and an IC₅₀ of 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC₅₀ of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment .

HY-116143

MAGL-IN-12	MAGL	Metabolic Disease
SAR127303 is an orally active, selective, competitive monoacylglycerol lipase (MAGL) covalent inhibitor with IC₅₀s of 3.8 nM and 29 nM for mouse and human MAGL, respectively. SAR127303 potently elevates hippocampal levels of 2-AG in mice. SAR127303 decreased long term potentiation (LTP) of CA1 synaptic transmission and acetylcholine release in the hippocampus. SAR127303 produces antinociceptive effects in assays of inflammatory and visceral pain. SAR127303 slows down epileptogenesis .

HY-147512

CB1/2 agonist 1	Cannabinoid Receptor	Inflammation/Immunology
CB1/2 agonist 1 is a potent and cross the blood-brain barrier CB1/2 agonist with EC₅₀s of 56.15, 11.63 nM for CB1R and CB2R, respectively. CB1/2 agonist 1 reduces glutamate release and LPS-induced activation of microglial cells. CB1/2 agonist 1 shows anti-inflammatory and antinociceptive effects. CB1/2 agonist 1 has the potential for the research of multiple sclerosis .

HY-18099

S1RA 1 Publications Verification E-52862	Sigma Receptor 5-HT Receptor	Neurological Disease
S1RA (E-52862) is a highly selective σ1 receptor (σ1R) antagonist with K_is of 17 nM and 23.5 nM for human σ1R and guinea pig σ1R, respectively. S1RA has Moderate antagonistic activity for human 5-HT_2B receptor (K_i= 328 nM). S1RA has antinociceptive effects in neuropathic pain models. S1RA prevents mechanical and cold hypersensitivity in Oxaliplatin (HY-17371)-treated mice .

HY-N6972

Cepharanthine 3 Publications Verification	SARS-CoV Cytochrome P450 Apoptosis Parasite	Infection Inflammation/Immunology Cancer
Cepharanthine is a natural product that can be isolated from the plant Stephania cephalantha Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50%) inhibitory concentration (IC₅₀) and 90% inhibitory concentration (IC₉₀) values of 1.90 and 4.46 µM . Cepharanthine can also effectively reverses P-gp-mediated multidrug resistance in K562 cells and increase enhances the sensitivity of anticancer agents in xenograft mice model . Cepharanthine shows inhibitory effects of human liver cytochrome P450 enzymes CYP3A4, CYP2E1 and CYP2C9. Cepharanthine has antitumor, anti-inflammatory and antinociceptive effects .

Cat. No.	Product Name	Category	Target	Chemical Structure